Sirano Dhe-Paganon serves as the Director and Principal Scientist at the Longwood Center for Structural & Chemical Biology within the Dana-Farber Cancer Institute, where he leads a dynamic team of biochemists and crystallographers. His expertise lies at the intersection of biochemistry and structural biology, focusing...
Sirano Dhe-Paganon serves as the Director and Principal Scientist at the Longwood Center for Structural & Chemical Biology within the Dana-Farber Cancer Institute, where he leads a dynamic team of biochemists and crystallographers. His expertise lies at the intersection of biochemistry and structural biology, focusing on elucidating complex molecular structures that are pivotal in understanding cancer mechanisms. Under his leadership, the center has become a hub for innovative research, where cutting-edge techniques such as X-ray crystallography and mass spectrometry are employed to develop novel chemical probes that can target specific pathways in cancer cells.
One of the key projects currently underway in Dhe-Paganon’s lab involves the structural characterization of protein complexes involved in tumorigenesis. By deciphering these intricate structures, his team aims to uncover potential therapeutic targets that can be leveraged for drug discovery. This work not only enhances the understanding of molecular mechanisms in cancer but also facilitates collaborations with principal investigators and industrial partners in the Harvard Medical area, driving forward translational research initiatives.
Dhe-Paganon’s extensive skill set includes advanced techniques in cell culture, PCR, and ELISA, which are integral to his research endeavors. His commitment to bridging the gap between basic science and clinical applications is evident in his approach to fostering a collaborative environment that encourages innovation. As a seasoned biochemist, he is dedicated to mentoring the next generation of scientists, ensuring that the Longwood Center remains at the forefront of biotechnological advancements in cancer research.
