Penglie Zhang serves as the Vice President and Head of Chemistry at ChemoCentryx, where he leverages his extensive expertise in small-molecule drug discovery and development to drive innovative therapeutic solutions. With a strong foundation in drug design and development, he has successfully led cross-functional teams...
Penglie Zhang serves as the Vice President and Head of Chemistry at ChemoCentryx, where he leverages his extensive expertise in small-molecule drug discovery and development to drive innovative therapeutic solutions. With a strong foundation in drug design and development, he has successfully led cross-functional teams comprising chemistry, biology, DMPK, and toxicology experts, fostering collaboration that has resulted in the discovery of over ten chemokine receptor antagonists. Notable among these are the clinical-stage compounds CCX354 and CCX507, which exemplify his ability to navigate projects from initial target evaluation through to IND-enabling studies and early-phase human trials.
In his current role, Penglie provides strategic oversight of the chemistry department, managing a talented team of up to 20 PhD and associate-level scientists. His leadership is characterized by a commitment to fostering a culture of innovation and excellence, ensuring that his team remains at the forefront of drug discovery. His proficiency in advanced analytical techniques such as LC-MS, HPLC, and NMR further enhances the department's capabilities, allowing for precise characterization and optimization of lead compounds.
Penglie's passion for drug discovery is evident in his work across multiple therapeutic areas, including immuno-oncology, autoimmune and inflammatory disorders, and cardiovascular diseases. His strategic vision and operational acumen have not only propelled projects forward but have also positioned ChemoCentryx as a leader in the pharmaceutical industry. As he continues to drive the development of groundbreaking therapies, Penglie remains dedicated to transforming scientific advancements into tangible benefits for patients worldwide.
