Neil Grodsky is a highly accomplished Senior Scientist at Pfizer, where he leverages over 15 years of extensive experience in structural biology to drive innovative research initiatives. His expertise spans a wide array of techniques including protein construct design, bacterial protein expression, and baculovirus preparation,...
Neil Grodsky is a highly accomplished Senior Scientist at Pfizer, where he leverages over 15 years of extensive experience in structural biology to drive innovative research initiatives. His expertise spans a wide array of techniques including protein construct design, bacterial protein expression, and baculovirus preparation, all of which are critical in the development of therapeutic proteins. Neil has made significant contributions to the field, notably by crystallizing and solving the first co-crystal structure of PKC-betaII, a pivotal achievement that has implications for drug discovery and development.
In his current role, Neil is at the forefront of protein purification and crystallization, utilizing advanced methodologies such as robotics and high-throughput screening to enhance efficiency and accuracy in his experiments. His work encompasses a diverse range of targets, including kinases, nuclear hormone receptors, and methyltransferases, which are integral to various therapeutic areas. By designing innovative protein constructs and executing co-crystallization experiments, he has successfully generated structural data that informs biochemical assays and therapeutic strategies.
Neil's proficiency in protein characterization and biophysics techniques—such as microscale thermophoresis (MST), dynamic light scattering (DLS), isothermal titration calorimetry (ITC), differential scanning calorimetry (DSC), and differential scanning fluorimetry (DSF)—enables him to provide comprehensive insights into protein behavior and interactions. As an effective team member, he collaborates with cross-functional project teams, contributing to Pfizer's mission of advancing healthcare through cutting-edge science. Neil's passion for structural biology and his commitment to innovation continue to drive impactful research outcomes that benefit patients worldwide.
