Ashish Saksule serves as the Principal Scientist and Cell & Gene Therapy Core Lead at Vertex Pharmaceuticals, where he plays a pivotal role in advancing innovative therapies through his extensive expertise in gene therapy bioprocessing. With a strong focus on both upstream and downstream process...
Ashish Saksule serves as the Principal Scientist and Cell & Gene Therapy Core Lead at Vertex Pharmaceuticals, where he plays a pivotal role in advancing innovative therapies through his extensive expertise in gene therapy bioprocessing. With a strong focus on both upstream and downstream process development, Ashish has been instrumental in establishing the Gene Therapy Vector Core lab, where he leads a dedicated scientific team in the optimization of lentiviral and adeno-associated virus (AAV) platforms. His leadership extends to the Cell Therapy Core lab, where he fosters a collaborative environment that drives the development of cutting-edge cell therapies.
Ashish’s proficiency in end-to-end bioprocessing encompasses critical areas such as analytical development and protein purification, ensuring that Vertex's therapeutic candidates meet stringent regulatory standards and maintain high-quality production. His technical skills, including expertise in scanning electron microscopy, SDS-PAGE, and process engineering, enable him to tackle complex challenges in gene therapy manufacturing. Additionally, his strategic acumen, combined with proficiency in tools like Aspen HYSYS and AutoCAD, allows him to streamline processes and enhance operational efficiency.
Key projects under Ashish's leadership have focused on the development of scalable manufacturing processes that are not only robust but also adaptable to the evolving landscape of gene and cell therapies. His commitment to innovation and excellence positions him as a thought leader in the field, driving forward Vertex Pharmaceuticals' mission to deliver transformative therapies to patients with serious diseases. Through his work, Ashish continues to contribute significantly to the advancement of biotherapeutics, shaping the future of medicine.
